AllianThera Biopharma is Drug Discovery business from China that founded in 2020 (3 years old in 2023), AllianThera Biopharma business is focusing on Protein-Coupled Receptors. Jobs at AllianThera Biopharma. 2023 SignalHire.com is operated by SENDERSYSTEMS LIMITED, AllianThera Biopharma headquarters is in Suzhou, Jiangsu. 6005 Hidden Valley Road Suite 110 Carlsbad, CA 92011 858-293-4900. 2016 Dec;15(12):3040-3054. doi: 10.1158/1535-7163.MCT-16-0313. Suzhou, Jiangsu PEM treatment co-opts cGAS-STING signaling in MET-amplified EGFR-TKIresistant cells. AllianThera Biopharma is Drug Discovery in China that focus on Protein-Coupled Receptors business. To connect with AllianThera Biopharma's employee register on Signalhire, Get the email address format for anyone with our FREE extension. PMC 6005 Hidden Valley Road Suite 110 Carlsbad, CA 92011 858-293-4900. Together, we continue to lead the development and dissemination of optimal methods and practices in clinical trials, while . A biparatopic antibody-drug conjugate to treat MET-expressing cancers, including those that are unresponsive to MET pathway blockade. Welcome to the Society for Clinical Trials (SCT). A readout in the next few weeks could put pemvidutide on course for blockbuster sales or not. Accessibility Pemetrexed (PEM), which is commonly used following EGFR-TKI treatment failure, was identified as an effective potentiator of STING-dependent TBK1-IRF3-STAT1 signaling in MET-amplified, EGFR-TKI-resistant cells. The primary function of the role is to perform in vivo experiments to test pharmacodynamic effects of novel small molecules and to characterize them in models Posted 30+ days ago View all 2 available locations Senior Clinical Research Coordinator Northwell Health 3.9 Manhasset, NY 11030 $70,000 - $79,300 a year Full-time Monday to Friday + 1 In the recent past, Dr. Ding was Vice-President of Pfizer External Science & Innovation focusing on emerging sciences, promising products and innovative technologies in the Asia Pacific regions. An official website of the United States government. Thursday, 25th of March 2021 (5:00AM EST) Today, AllianThera Biopharma (ATB), a Suzhou, China-based startup focusing on inventing and . 328 Xinghu Street, Suzhou Industrial Park, Suzhou Area, China (Jiangsu) Pilot Free Trade Zone. We use cookies on this website. However, PEM treatment also induced adenosine production, which inhibited T-cell responsiveness. If this sounds like you, please get in touch with us. Shi P, Oh YT, Zhang G, Yao W, Yue P, Li Y, Kanteti R, Riehm J, Salgia R, Owonikoko TK, Ramalingam SS, Chen M, Sun SY. Now, says Dr. Levitt, Insilico Medicine is using AI to create an entirely new AI-driven drug discovery pipeline from A to Z. Dr. Ding and Dr. Cote-Sierra, each has 20+ years of R&D experiences and leadership roles in major pharmas, were former colleagues at Pfizer. Company. Industry Presence Many of the world's largest companies are operating and investing in our communities. 700, Boston, MA 02110. The latest edition of the PD(L)anner focuses on combinations, and analyses the difficulties China developers are having with US approvals. Show more AllianThera Biopharma headquarters is in Suzhou, Jiangsu. Chills in the biopharma M&A market are frequently blamed on the FTC. The https:// ensures that you are connecting to the 12 Dana-Farber Cancer Institute, Boston, United States. In this role, Dr. Ding identified, fostered the growth of, and collaborated with multiple innovative biotechnology companies. view more Credit: Insilico Medicine. Developer of GPCR-targeted drug. ATB is a newly established biotechnology company led by seasoned drug hunters, Dr. Yuan-Hua Ding (CEO) and Dr. Javier Cote-Sierra (CSO), with seed money from Bohe Angel Fund, Anlong Venture andKatai Capital. PEM-induced immunogenicity is restrained by CD73. Clin Transl Oncol. What you see here scratches the surface Request a free trial 13 Dana-Farber Cancer Institute, Boston, Massachusetts, United States. See this image and copyright information in PMC. Efforts to enhance the immunogenicity of EGFR-mutated lung cancer have been unsuccessful to date. -, Le X, Puri S, Negrao MV, Nilsson MB, Robichaux J, Boyle T, et al. Since 2014 Insilico Medicine is focusing on generative models, reinforcement learning (RL), and other modern machine learning techniques for the generation of new molecular structures with the specified parameters, generation of synthetic biological data, target identification, and prediction of clinical trials outcomes. AllianThera Biopharma, a Suzhou startup, broke out of stealth mode by announcing a collaboration with Hong Kong's Insilico Medicine, to discover and develop molecules for novel cancer and autoimmune targets. * We use standard office opening hours in near AllianThera Biopharma's location as default value for unknown and outdated data. Terms were not disclosed. AllianThera Biopharma Updated February 18, 2023 Popular Jobs on Glassdoor Mechanical Engineer Jobs IT Jobs Human Resource Jobs Healthcare Jobs Graphic Designer Jobs Account Executive Jobs Registered Nurse Jobs Pharmaceutical Sales Jobs Guide to Getting Your First Job Find a Great First Job to Jumpstart Your Career How to Get a Job Co-Founder & CSO of Allianthera Biopharma and Former Head of Inflammation & Immunology External Innovation at Sanofi Genzyme Yuan-Hua Ding, PhD Advisor Co-Founder & CEO of Allianthera Biopharma and Co-CEO at the BayRay Innovation Center, former Head of Pfizer Asia Discovery Labs sharing sensitive information, make sure youre on a federal We also use them to share usage information with our partners. Epub 2019 Mar 12. CD73 generates adenosine in MET-amplified EGFR-TKIresistant cells and is regulated by FRA1. Bethesda, MD 20894, Web Policies In 2023, AllianThera Biopharma is currently focus on Protein-Coupled Receptors sector. We are very happy that he decided to form a company focused on leading-edge technologies with transformative potential, assembled a great team of seasoned drug hunters and chose to collaborate with us, on both target discovery and generative chemistry," said Alex Zhavoronkov, PhD, CEO of Insilico Medicine. Using a physiologic antigen recognition model, inactivation of CD73 significantly increased antigen-specific CD8+ T-cell immunogenicity following PEM treatment. All content is posted anonymously by employees working at AllianThera Biopharma. Get involved to accelerate your cross-border partnering strategies. 2022 The Authors; Published by the American Association for Cancer Research. Acquired Resistance Mechanisms to Combination Met-TKI/EGFR-TKI Exposure in Met-Amplified EGFR-TKI-Resistant Lung Adenocarcinoma Harboring an Activating EGFR Mutation. 11 Allianthera Biopharma, Natick, MA, United States. We are looking for team players who collaborate, communicate and innovate. Go to your account and send up to 300 emails per day using the Free plan. Shanghai: Unit 04-08, 5F, Platinum Building, No.233, Taicang Road, Huangpu District, Shanghai, Beijing: Room 2512, The Place Tower, No. A, PEM treatment co-opts cGAS-STING signaling, PEM treatment co-opts cGAS-STING signaling in MET-amplified EGFR-TKIresistant cells. Ai-biopharma - Ai powered drug discovery All fields are required. -, Soria JC, Ohe Y, Vansteenkiste J, Reungwetwattana T, Chewaskulyong B, Lee KH, et al. Altimmune aims to build Momentum in obesity, Go or no go? Clin Lung Cancer. About ATB (AllianThera Biopharma): Founded by a group of veteran pharma scientists, ATB strives to become a global leader in therapeutic innovation by combining our deep disease biology knowledge and 1F C1, No. Recently, Insilico Medicine secured $37 million in series B funding. The data displayed is available through open government websites and public online directory. Massachusetts Biotechnology Council. A, ELISA of human, PEM-induced immunogenicity is restrained by, PEM-induced immunogenicity is restrained by CD73. ATB is funded by Anlong Venture, Bohe Angel Fund and Katai Capital. Allianthera Boston, Inc. is a Massachusetts Domestic Profit Corporation filed on March 25, 2021. Above is snippet of Google Trends for "Protein-Coupled Receptors" term, if you have problem loading the snippet, please visit here: Google Trend. Federal government websites often end in .gov or .mil. Mol Cancer Ther 2021;20:196676. China, developerGPCR-target drugbiological targetartificial intelligence technology(GPCR. FOIA Linkedin. Dr. Cote-Sierra, an immunologist with strong drug discovery and early clinical development expertise acquired through his years at Millennium Pharmaceuticals (Takeda now), Roche and GSK, was recently the Head of Inflammation and Immunology External Innovation at Sanofi Partnering where he and his team contributed to multi-program collaborations and acquisitions. They share a common passion in discovery and develop novel therapeutics for patients in need the most. and transmitted securely. Disclaimer: AAAS and EurekAlert! AllianThera Biopharma (ATB), a Suzhou, China-based startup focusing on inventing and developing innovative medicines for a broad range of diseases, and Insilico Medicine, a global leader in deep learning for drug discovery and development, have announced a collaboration to discover and develop molecules for novel targets in cancer and autoimmune diseases. Terms and Conditions I agree to the terms of the Usage AgreementI agree to the terms of the Privacy Policy Create My Account Site Map Terms of Use Privacy Policy Search Jobs. Met gene amplification and protein hyperactivation is a mechanism of resistance to both first and third generation EGFR inhibitors in lung cancer treatment. Systematic genomic analyses and cell line studies confirmed upregulation of CD73 in MET-amplified and MET-activated lung cancer contexts, which depends on coinduction of FOSL1. government site. The cytosolic DNA-sensing cGAS-STING pathway in cancer. SUZHOU, China, March 25, 2021 /PRNewswire/ --Today, AllianThera Biopharma (ATB), a Suzhou, China-based startup focusing on inventing and developing innovative medicines for a broad range of diseases, and Insilico Medicine, a global leader in deep learning for drug discovery and development, announced a collaboration to discover and develop molecules for novel targets in cancer and autoimmune diseases. work@designtx.com. Explore the options below to learn more about how you can get involved. Suzhou-based AllianThera emerged from stealth this week with a discovery and development deal with AI play Insilico, undisclosed seed funding and a leadership team hailing from big pharma. Websitehttp://insilico.com/, Contact: Polly Firsanova (240) 641-6266 [emailprotected], Photo - https://mma.prnewswire.com/media/1473235/Insilico_AllianThera_Biopharma.jpg, https://mma.prnewswire.com/media/1473235/Insilico_AllianThera_Biopharma.jpg. 700 Technology Square, 5th Floor Cambridge, MA 02139 617.674.5100 Cells 2018;7:212. Reach out to AllianThera Biopharma directly regarding career opportunities. Unauthorized use of these marks is strictly prohibited. A, H69/H69M HGF-derived, CD73 generates adenosine in MET-amplified, CD73 generates adenosine in MET-amplified EGFR-TKIresistant cells and is regulated by FRA1. Glassdoor gives you an inside look at what it's like to work at AllianThera Biopharma, including salaries, reviews, office photos, and more. Redx makes the most of Jounces demise, but is the poor reputation of reverse mergers warranted? ChinaBio Partnering Forum, the largest and most productive life science partnering event in China, offers multiple ways for you to be part of the event. Cancer Discov 2020;10:2639. All rights reserved. Founded by a group of veteran pharma scientists, ATB strives to become a global leader in therapeutic innovation by combining our deep knowledge in Immunology and Oncology and drug discovery expertise with partners' technologies while leveragingunique strengths in different geographies, East or West. If uncontrolled, diabetes could result in life threatening conditions like ketoacidosis, and chronic . Yamaoka T, Ohmori T, Ohba M, Arata S, Kishino Y, Murata Y, Kusumoto S, Ishida H, Shirai T, Hirose T, Ohnishi T, Sasaki Y. Mol Cancer Ther. Business Type Drug Discovery Country China Founded 2020 ( 3 years old in 2023 ) Company Focus 8600 Rockville Pike "Dr. Ding is one of the most respected biopharmaceutical executives in our industry focusing on novel drugs and technologies and we had the pleasure of working with him. 2009 Jul;10(4):281-9. doi: 10.3816/CLC.2009.n.039. official website and that any information you provide is encrypted Founder of Allianthera Biopharma Co. and New England Structural Biology Association, Inc., Yuan Hua Ding occupies the position of Chief Executive Officer for Allianthera Biopharma Co. and Chief. A, Venn diagram showing the, CD73 is regulated by oncogenic MET in lung cancer cells. Landscape of EGFR-dependent and -independent resistance mechanisms to osimertinib and continuation therapy beyond progression in EGFR-mutant NSCLC. . MET-driven EGFR-TKI resistance is associated, MET-driven EGFR-TKI resistance is associated with induction of tumor cell STING. 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